Assay Detail
Functional
CHEMBL4377509
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Antiproliferative activity against human H1299 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.81 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4548580 | — | — | 1 | 6.69 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | 5.63 |
| CHEMBL48802 | SULFORAPHANE | 3.0 | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4548580 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL3545110 | RIBOCICLIB | IC50 | = | 2349.0 | nM | 5.63 |
| CHEMBL48802 | SULFORAPHANE | IC50 | = | 7648.0 | nM | 5.12 |