Assay Detail

CHEMBL4378100

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antimalarial activity against mefloquine/chloroquine-resistant Plasmodium falciparum asexual blood stage forms

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.

Ashton TD, Devine SM, Möhrle JJ, Laleu B, Burrows JN, Charman SA, Creek DJ, Sleebs BE.
J Med Chem (2019) 62 : 10526 -10562
PubMed 31385706 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.15	8.15

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1956285	DSM-265	2.0	1	8.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1956285	DSM-265	EC50	=	7.0	nM	8.15