Assay Detail

CHEMBL4378138

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Binding

Inhibition of Plasmodium vivax PI4K

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Plasmodium vivax
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.

Ashton TD, Devine SM, Möhrle JJ, Laleu B, Burrows JN, Charman SA, Creek DJ, Sleebs BE.
J Med Chem (2019) 62 : 10526 -10562
PubMed 31385706 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.47	8.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2041980	MMV-048	2.0	1	8.47

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2041980	MMV-048	IC50	=	3.4	nM	8.47