Assay Detail
Binding
CHEMBL4378233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALK (unknown origin)
17
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.45 | 9.30 |
| Ki | 2 | 9.12 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464552 | — | — | 1 | 9.30 |
| CHEMBL4203266 | — | — | 1 | 9.12 |
| CHEMBL4436406 | — | — | 2 | 9.00 |
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 9.00 |
| CHEMBL2172315 | — | — | 1 | 9.00 |
| CHEMBL2172308 | — | — | 1 | 8.92 |
| CHEMBL1779202 | — | — | 1 | 8.82 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 8.72 |
| CHEMBL4476742 | — | — | 1 | 8.70 |
| CHEMBL3735401 | — | — | 1 | 8.70 |
| CHEMBL1823221 | — | — | 1 | 8.54 |
| CHEMBL2172323 | — | — | 1 | 8.52 |
| CHEMBL1779192 | — | — | 1 | 8.12 |
| CHEMBL2042829 | — | — | 1 | 7.85 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.70 |
| CHEMBL1779097 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464552 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4203266 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL4436406 | — | IC50 | = | 1.01 | nM | 9.00 |
| CHEMBL2172315 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 1.01 | nM | 9.00 |
| CHEMBL2172308 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1779202 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1738797 | ALECTINIB | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4476742 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3735401 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1823221 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2172323 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1779192 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL2042829 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1779097 | — | IC50 | = | 1336.0 | nM | 5.87 |
| CHEMBL4436406 | — | Ki | < | 0.02 | nM | - |