Assay Detail
Functional
CHEMBL4378238
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Antiproliferative activity against human KARPAS299 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.83 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 8.52 |
| CHEMBL1823221 | — | — | 1 | 7.89 |
| CHEMBL1779202 | — | — | 1 | 7.67 |
| CHEMBL1779192 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1738797 | ALECTINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1823221 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL1779202 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL1779192 | — | IC50 | = | 60.0 | nM | 7.22 |