Assay Detail
Binding
CHEMBL4378240
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Inhibition of ALK in mouse NIH-3T3 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.56 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4573293 | — | — | 1 | 9.15 |
| CHEMBL3128069 | — | — | 1 | 9.10 |
| CHEMBL4436406 | — | — | 1 | 8.89 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4573293 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3128069 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4436406 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 80.0 | nM | 7.10 |