Assay Detail
Binding
CHEMBL4378241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALK L1196M mutant in mouse NIH-3T3 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.64 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3128069 | — | — | 1 | 9.10 |
| CHEMBL4573293 | — | — | 1 | 8.18 |
| CHEMBL4436406 | — | — | 1 | 7.68 |
| CHEMBL3128064 | — | — | 1 | 7.57 |
| CHEMBL3128074 | — | — | 1 | 7.22 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3128069 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4573293 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4436406 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3128064 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3128074 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 843.0 | nM | 6.07 |