Assay Detail
Binding
CHEMBL4378243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALK L1196M (unknown origin)
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.92 | 9.70 |
| Ki | 1 | 9.15 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3128069 | — | — | 1 | 9.70 |
| CHEMBL4436406 | — | — | 2 | 9.15 |
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 8.97 |
| CHEMBL4573293 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3128069 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4436406 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4436406 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL4573293 | — | IC50 | = | 14.0 | nM | 7.85 |