Assay Detail
Binding
CHEMBL4378244
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Inhibition of ALK G1202R (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.21 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 8.90 |
| CHEMBL3735401 | — | — | 1 | 8.70 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 8.68 |
| CHEMBL3747406 | — | — | 1 | 7.68 |
| CHEMBL4436406 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL3735401 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1738797 | ALECTINIB | IC50 | = | 2.07 | nM | 8.68 |
| CHEMBL3747406 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4436406 | — | IC50 | = | 77.0 | nM | 7.11 |