Assay Detail

CHEMBL4378248

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Functional

Cytotoxicity against human NCI-H3122 cells harboring EML4-ALK E13;A20 mutant incubated for 72 hrs by Cell titer blue assay

ChEMBL ↗

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Target

NCI-H3122 (CHEMBL4296475) ↗

Open DB target context

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NCI-H3122 (CHEMBL4296475) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NCI-H3122

CHEMBL4296475

Anchored from Assay target.

Protein identity NCI-H3122

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H3122
Confidence	1 — Organism
Curated By	Autocuration

Target

NCI-H3122 (CHEMBL4296475) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).

Kong X, Pan P, Sun H, Xia H, Wang X, Li Y, Hou T.
J Med Chem (2019) 62 : 10927 -10954
PubMed 31419130 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.29	7.82

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4113131	ENSARTINIB	4.0	1	7.82
CHEMBL601719	CRIZOTINIB	4.0	1	6.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4113131	ENSARTINIB	IC50	=	15.0	nM	7.82
CHEMBL601719	CRIZOTINIB	IC50	=	180.0	nM	6.75