Assay Detail
Binding
CHEMBL4378468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged-Mcl1 (E171 to G327) (unknown origin) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide C as substrate incubated for 120 to 180 mins by TR-FRET assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hot-Spots of Mcl-1 Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.67 | 7.38 |
| Ki | 1 | 9.70 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297482 | AZD-5991 | 1.0 | 1 | 9.70 |
| CHEMBL4443085 | — | — | 1 | 7.38 |
| CHEMBL3417691 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297482 | AZD-5991 | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4443085 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3417691 | — | IC50 | = | 1100.0 | nM | 5.96 |