Assay Detail
Binding
CHEMBL4378475
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Inhibition of human GST-tagged BCL-XL deltaC25 mutant using biotinylated BIM 26-mer peptide as substrate incubated for 30 mins by AlphaScreen assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hot-Spots of Mcl-1 Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.12 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287282 | — | — | 1 | 7.64 |
| CHEMBL3400497 | — | — | 1 | 7.62 |
| CHEMBL4561067 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287282 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3400497 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4561067 | — | IC50 | = | 770.0 | nM | 6.11 |