Assay Detail
Binding
CHEMBL4378476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild-type BCL-2 (unknown origin) expressed in Escherichia coli BL21 cells using biotinylated BIMBH3 or BAXBH3 peptide by surface plasmon resonance assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hot-Spots of Mcl-1 Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 10.09 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 10.74 |
| CHEMBL4561305 | — | — | 1 | 9.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137309 | VENETOCLAX | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL4561305 | — | Ki | = | 0.36 | nM | 9.44 |