Assay Detail
Functional
CHEMBL4378591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against doxorubicin-resistant human RPMI8226/S cells after 4 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.12 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.50 |
| CHEMBL346068 | — | — | 1 | 6.30 |
| CHEMBL155344 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL346068 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL155344 | — | IC50 | = | 2800.0 | nM | 5.55 |