Assay Detail
Binding
CHEMBL4378746
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Inhibition of RIPK1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL5464) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474235 | — | — | 1 | 7.68 |
| CHEMBL395358 | — | — | 1 | 7.13 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474235 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL395358 | — | IC50 | = | 73.6 | nM | 7.13 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 1500.0 | nM | 5.82 |