Assay Detail
ADMET
CHEMBL4379868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human carbonic anhydrase 2 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.06 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.90 |
| CHEMBL4453203 | — | — | 1 | 6.85 |
| CHEMBL4437873 | — | — | 1 | 6.84 |
| CHEMBL3976024 | — | — | 1 | 6.82 |
| CHEMBL4474233 | — | — | 1 | 6.32 |
| CHEMBL4542190 | — | — | 1 | 6.28 |
| CHEMBL4571323 | — | — | 1 | 6.27 |
| CHEMBL4550437 | — | — | 1 | 6.16 |
| CHEMBL4587101 | — | — | 1 | 6.12 |
| CHEMBL4521083 | — | — | 1 | 6.07 |
| CHEMBL4553482 | — | — | 1 | 6.06 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 6.02 |
| CHEMBL4449637 | — | — | 1 | 5.97 |
| CHEMBL4586255 | — | — | 1 | 5.94 |
| CHEMBL4531304 | — | — | 1 | 5.72 |
| CHEMBL4435951 | — | — | 1 | 5.66 |
| CHEMBL4539322 | — | — | 1 | 5.63 |
| CHEMBL4469385 | — | — | 1 | 5.63 |
| CHEMBL4440314 | — | — | 1 | 5.61 |
| CHEMBL4536306 | — | — | 1 | 5.53 |
| CHEMBL4444406 | — | — | 1 | 5.52 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 5.22 |
| CHEMBL4442867 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL4453203 | — | Ki | = | 140.1 | nM | 6.85 |
| CHEMBL4437873 | — | Ki | = | 143.8 | nM | 6.84 |
| CHEMBL3976024 | — | Ki | = | 150.3 | nM | 6.82 |
| CHEMBL4474233 | — | Ki | = | 483.6 | nM | 6.32 |
| CHEMBL4542190 | — | Ki | = | 526.9 | nM | 6.28 |
| CHEMBL4571323 | — | Ki | = | 533.6 | nM | 6.27 |
| CHEMBL4550437 | — | Ki | = | 685.5 | nM | 6.16 |
| CHEMBL4587101 | — | Ki | = | 763.5 | nM | 6.12 |
| CHEMBL4521083 | — | Ki | = | 853.1 | nM | 6.07 |
| CHEMBL4553482 | — | Ki | = | 871.7 | nM | 6.06 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL4449637 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL4586255 | — | Ki | = | 1141.0 | nM | 5.94 |
| CHEMBL4531304 | — | Ki | = | 1922.0 | nM | 5.72 |
| CHEMBL4435951 | — | Ki | = | 2192.0 | nM | 5.66 |
| CHEMBL4539322 | — | Ki | = | 2362.0 | nM | 5.63 |
| CHEMBL4469385 | — | Ki | = | 2337.0 | nM | 5.63 |
| CHEMBL4440314 | — | Ki | = | 2445.0 | nM | 5.61 |
| CHEMBL4536306 | — | Ki | = | 2936.0 | nM | 5.53 |
| CHEMBL4444406 | — | Ki | = | 3024.0 | nM | 5.52 |
| CHEMBL310671 | SACCHARIN | Ki | = | 5950.0 | nM | 5.22 |
| CHEMBL4442867 | — | Ki | = | 6775.0 | nM | 5.17 |