Assay Detail
Binding
CHEMBL4379871
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Inhibition of recombinant human carbonic anhydrase 9 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.14 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571323 | — | — | 1 | 7.72 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL4587101 | — | — | 1 | 7.59 |
| CHEMBL4550437 | — | — | 1 | 7.55 |
| CHEMBL4539322 | — | — | 1 | 7.51 |
| CHEMBL4531304 | — | — | 1 | 7.45 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 7.35 |
| CHEMBL4553482 | — | — | 1 | 7.34 |
| CHEMBL4586255 | — | — | 1 | 7.25 |
| CHEMBL4453203 | — | — | 1 | 7.23 |
| CHEMBL4474233 | — | — | 1 | 7.22 |
| CHEMBL4437873 | — | — | 1 | 7.19 |
| CHEMBL4542190 | — | — | 1 | 7.13 |
| CHEMBL3976024 | — | — | 1 | 7.10 |
| CHEMBL4444406 | — | — | 1 | 7.05 |
| CHEMBL4440314 | — | — | 1 | 7.04 |
| CHEMBL4442867 | — | — | 1 | 7.01 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.99 |
| CHEMBL4521083 | — | — | 1 | 6.86 |
| CHEMBL4469385 | — | — | 1 | 6.72 |
| CHEMBL4449637 | — | — | 1 | 6.56 |
| CHEMBL4435951 | — | — | 1 | 6.43 |
| CHEMBL4536306 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571323 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4587101 | — | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL4550437 | — | Ki | = | 28.2 | nM | 7.55 |
| CHEMBL4539322 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4531304 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL4553482 | — | Ki | = | 45.8 | nM | 7.34 |
| CHEMBL4586255 | — | Ki | = | 56.9 | nM | 7.25 |
| CHEMBL4453203 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL4474233 | — | Ki | = | 60.2 | nM | 7.22 |
| CHEMBL4437873 | — | Ki | = | 63.9 | nM | 7.19 |
| CHEMBL4542190 | — | Ki | = | 73.3 | nM | 7.13 |
| CHEMBL3976024 | — | Ki | = | 78.7 | nM | 7.10 |
| CHEMBL4444406 | — | Ki | = | 88.1 | nM | 7.05 |
| CHEMBL4440314 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL4442867 | — | Ki | = | 98.7 | nM | 7.01 |
| CHEMBL310671 | SACCHARIN | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL4521083 | — | Ki | = | 139.5 | nM | 6.86 |
| CHEMBL4469385 | — | Ki | = | 188.9 | nM | 6.72 |
| CHEMBL4449637 | — | Ki | = | 273.4 | nM | 6.56 |
| CHEMBL4435951 | — | Ki | = | 367.6 | nM | 6.43 |
| CHEMBL4536306 | — | Ki | = | 408.5 | nM | 6.39 |