Assay Detail
Binding
CHEMBL4379872
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Inhibition of recombinant human carbonic anhydrase 12 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.16 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4442867 | — | — | 1 | 7.81 |
| CHEMBL4571323 | — | — | 1 | 7.60 |
| CHEMBL4440314 | — | — | 1 | 7.57 |
| CHEMBL4444406 | — | — | 1 | 7.46 |
| CHEMBL4587101 | — | — | 1 | 7.42 |
| CHEMBL4453203 | — | — | 1 | 7.37 |
| CHEMBL4550437 | — | — | 1 | 7.37 |
| CHEMBL3976024 | — | — | 1 | 7.28 |
| CHEMBL4531304 | — | — | 1 | 7.19 |
| CHEMBL4437873 | — | — | 1 | 7.16 |
| CHEMBL4586255 | — | — | 1 | 7.15 |
| CHEMBL4553482 | — | — | 1 | 7.13 |
| CHEMBL4542190 | — | — | 1 | 7.12 |
| CHEMBL4539322 | — | — | 1 | 7.01 |
| CHEMBL4474233 | — | — | 1 | 6.98 |
| CHEMBL4521083 | — | — | 1 | 6.74 |
| CHEMBL4449637 | — | — | 1 | 6.61 |
| CHEMBL4469385 | — | — | 1 | 6.49 |
| CHEMBL4435951 | — | — | 1 | 6.34 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.20 |
| CHEMBL4536306 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4442867 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL4571323 | — | Ki | = | 24.9 | nM | 7.60 |
| CHEMBL4440314 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL4444406 | — | Ki | = | 34.6 | nM | 7.46 |
| CHEMBL4587101 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL4453203 | — | Ki | = | 42.7 | nM | 7.37 |
| CHEMBL4550437 | — | Ki | = | 42.5 | nM | 7.37 |
| CHEMBL3976024 | — | Ki | = | 53.1 | nM | 7.28 |
| CHEMBL4531304 | — | Ki | = | 64.5 | nM | 7.19 |
| CHEMBL4437873 | — | Ki | = | 69.3 | nM | 7.16 |
| CHEMBL4586255 | — | Ki | = | 70.8 | nM | 7.15 |
| CHEMBL4553482 | — | Ki | = | 74.3 | nM | 7.13 |
| CHEMBL4542190 | — | Ki | = | 75.8 | nM | 7.12 |
| CHEMBL4539322 | — | Ki | = | 96.6 | nM | 7.01 |
| CHEMBL4474233 | — | Ki | = | 104.9 | nM | 6.98 |
| CHEMBL4521083 | — | Ki | = | 181.5 | nM | 6.74 |
| CHEMBL4449637 | — | Ki | = | 247.2 | nM | 6.61 |
| CHEMBL4469385 | — | Ki | = | 325.7 | nM | 6.49 |
| CHEMBL4435951 | — | Ki | = | 458.7 | nM | 6.34 |
| CHEMBL310671 | SACCHARIN | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL4536306 | — | Ki | = | 764.0 | nM | 6.12 |