Assay Detail
Functional
CHEMBL4379877
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Antiproliferative activity against human A549 cells measured after 72 hrs under normoxic condition by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.05 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3976024 | — | — | 1 | 5.45 |
| CHEMBL4587101 | — | — | 1 | 5.32 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 5.13 |
| CHEMBL4550437 | — | — | 1 | 4.96 |
| CHEMBL4571323 | — | — | 1 | 4.74 |
| CHEMBL4521083 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3976024 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4587101 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL4550437 | — | IC50 | = | 10880.0 | nM | 4.96 |
| CHEMBL4571323 | — | IC50 | = | 18320.0 | nM | 4.74 |
| CHEMBL4521083 | — | IC50 | = | 19860.0 | nM | 4.70 |