Assay Detail
Functional
CHEMBL4379879
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Antiproliferative activity against human PC3 cells measured after 72 hrs under normoxic condition by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.95 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 5.31 |
| CHEMBL4587101 | — | — | 1 | 5.20 |
| CHEMBL4571323 | — | — | 1 | 4.92 |
| CHEMBL3976024 | — | — | 1 | 4.86 |
| CHEMBL4550437 | — | — | 1 | 4.79 |
| CHEMBL4521083 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL4587101 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL4571323 | — | IC50 | = | 11980.0 | nM | 4.92 |
| CHEMBL3976024 | — | IC50 | = | 13950.0 | nM | 4.86 |
| CHEMBL4550437 | — | IC50 | = | 16230.0 | nM | 4.79 |
| CHEMBL4521083 | — | IC50 | = | 23760.0 | nM | 4.62 |