Assay Detail
Binding
CHEMBL4380030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat kidney ALR1 using sodium D-glucuronate as substrate incubated for 1 min and measured up to 4 mins using H2O-dissolved compound by spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.58 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4566195 | — | — | 1 | 4.70 |
| CHEMBL1405739 | — | — | 1 | 4.46 |
| CHEMBL4582264 | — | — | 1 | - |
| CHEMBL4541343 | — | — | 1 | - |
| CHEMBL4462469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4566195 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL1405739 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4582264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4541343 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4462469 | — | IC50 | > | 100000.0 | nM | - |