Assay Detail
Binding
CHEMBL4380258
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Binding affinity to Staphylococcus saprophyticus nitroreductase NtrB
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus saprophyticus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Putative nitroreductase (CHEMBL4523956) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM20229 / NCIMB 8711 / NCTC 7292 / S-41) |
Publication
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.74 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564160 | — | — | 1 | 6.55 |
| CHEMBL4442911 | — | — | 1 | 6.05 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 5.22 |
| CHEMBL281812 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564160 | — | Ki | = | 283.49 | nM | 6.55 |
| CHEMBL4442911 | — | Ki | = | 895.67 | nM | 6.05 |
| CHEMBL23330 | TRETAZICAR | Ki | = | 5960.0 | nM | 5.22 |
| CHEMBL281812 | — | Ki | = | 7280.0 | nM | 5.14 |