Assay Detail
Functional
CHEMBL4380272
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Antiproliferative activity against human HCC1937 cells measured after 7 days by Celltiter-glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC1937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.50 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470724 | — | — | 1 | 5.98 |
| CHEMBL4438741 | — | — | 1 | 5.46 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 5.34 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470724 | — | IC50 | = | 1047.13 | nM | 5.98 |
| CHEMBL4438741 | — | IC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 6309.57 | nM | 5.20 |