Assay Detail
Functional
CHEMBL4380274
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Antiproliferative activity against human MDA-MB-468 cells measured after 7 days by Celltiter-glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.47 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470724 | — | — | 1 | 6.01 |
| CHEMBL4438741 | — | — | 1 | 5.59 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 5.40 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470724 | — | IC50 | = | 977.24 | nM | 6.01 |
| CHEMBL4438741 | — | IC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 13803.84 | nM | 4.86 |