Assay Detail
Binding
CHEMBL4380526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild-type human partial length DRAK1 (R32 to E363 residues) expressed in bacterial expression system by Kinomescan method
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.21 | 7.82 |
| Kd | 3 | 8.12 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435393 | — | — | 1 | 8.30 |
| CHEMBL4549459 | — | — | 1 | 8.05 |
| CHEMBL4553949 | — | — | 1 | 8.00 |
| CHEMBL4436188 | — | — | 1 | 7.82 |
| CHEMBL4594167 | — | — | 1 | 7.60 |
| CHEMBL4566796 | — | — | 1 | 7.52 |
| CHEMBL4453292 | — | — | 1 | 6.60 |
| CHEMBL4537673 | BAY-985 | — | 1 | 6.51 |
| CHEMBL4466150 | — | — | 1 | - |
| CHEMBL4547610 | — | — | 1 | - |
| CHEMBL4436416 | — | — | 1 | - |
| CHEMBL4453481 | — | — | 1 | - |
| CHEMBL4468020 | — | — | 1 | - |
| CHEMBL4515413 | — | — | 1 | - |
| CHEMBL4451595 | — | — | 1 | - |
| CHEMBL4552254 | — | — | 1 | - |
| CHEMBL4538751 | — | — | 1 | - |
| CHEMBL4454902 | — | — | 1 | - |
| CHEMBL4543618 | — | — | 1 | - |
| CHEMBL4538591 | BAY-440 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435393 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL4549459 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL4553949 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4436188 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4594167 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4566796 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4453292 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4537673 | BAY-985 | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL4466150 | — | IC50 | - | — | - | |
| CHEMBL4547610 | — | IC50 | - | — | - | |
| CHEMBL4436416 | — | IC50 | - | — | - | |
| CHEMBL4453481 | — | IC50 | - | — | - | |
| CHEMBL4468020 | — | IC50 | - | — | - | |
| CHEMBL4515413 | — | IC50 | - | — | - | |
| CHEMBL4451595 | — | IC50 | - | — | - | |
| CHEMBL4552254 | — | IC50 | - | — | - | |
| CHEMBL4538751 | — | IC50 | - | — | - | |
| CHEMBL4454902 | — | IC50 | - | — | - | |
| CHEMBL4543618 | — | IC50 | - | — | - | |
| CHEMBL4538591 | BAY-440 | IC50 | - | — | - |