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Assay Detail

CHEMBL4380527

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of wild-type human partial length ULK1 (M1 to T309 residues) expressed in mammalian expression system by Kinomescan method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase ULK1 (CHEMBL6006)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor.
Lefranc J, Schulze VK, Hillig RC, Briem H, Prinz F, Mengel A, Heinrich T, Balint J, Rengachari S, Irlbacher H, Stöckigt D, Bömer U, Bader B, Gradl SN, Nising CF, von Nussbaum F, Mumberg D, Panne D, Wengner AM.
J Med Chem (2020) 63 : 601 -612
PubMed 31859507 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.49 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4435393 1 8.05
CHEMBL4468020 1 7.55
CHEMBL4543618 1 6.58
CHEMBL4566796 1 6.43
CHEMBL4454902 1 6.38
CHEMBL4538751 1 6.01
CHEMBL4594167 1 5.79
CHEMBL4537673 BAY-985 1 5.10
CHEMBL4553949 1 -
CHEMBL4466150 1 -
CHEMBL4547610 1 -
CHEMBL4436416 1 -
CHEMBL4453481 1 -
CHEMBL4436188 1 -
CHEMBL4515413 1 -
CHEMBL4549459 1 -
CHEMBL4552254 1 -
CHEMBL4453292 1 -
CHEMBL4538591 BAY-440 1 -
CHEMBL4451595 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4435393 IC50 = 9.0 nM 8.05
CHEMBL4468020 IC50 = 28.0 nM 7.55
CHEMBL4543618 IC50 = 263.0 nM 6.58
CHEMBL4566796 IC50 = 368.0 nM 6.43
CHEMBL4454902 IC50 = 416.0 nM 6.38
CHEMBL4538751 IC50 = 980.0 nM 6.01
CHEMBL4594167 IC50 = 1640.0 nM 5.79
CHEMBL4537673 BAY-985 IC50 = 7930.0 nM 5.10
CHEMBL4553949 IC50 - -
CHEMBL4466150 IC50 - -
CHEMBL4547610 IC50 - -
CHEMBL4436416 IC50 - -
CHEMBL4453481 IC50 - -
CHEMBL4436188 IC50 - -
CHEMBL4515413 IC50 - -
CHEMBL4549459 IC50 - -
CHEMBL4552254 IC50 - -
CHEMBL4453292 IC50 > 10000.0 nM -
CHEMBL4538591 BAY-440 IC50 - -
CHEMBL4451595 IC50 - -