Assay Detail
Functional
CHEMBL4380650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 4.71 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4537640 | — | — | 1 | 6.00 |
| CHEMBL4564211 | — | — | 1 | 6.00 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.57 |
| CHEMBL4439487 | — | — | 1 | 5.24 |
| CHEMBL4557430 | — | — | 1 | 4.97 |
| CHEMBL4530236 | — | — | 1 | 4.94 |
| CHEMBL4448269 | — | — | 1 | 4.91 |
| CHEMBL4467299 | — | — | 1 | 4.88 |
| CHEMBL4441228 | — | — | 1 | 4.87 |
| CHEMBL4539993 | — | — | 1 | 4.80 |
| CHEMBL4441086 | — | — | 1 | 4.78 |
| CHEMBL4551086 | — | — | 1 | 4.70 |
| CHEMBL463165 | — | — | 1 | 4.66 |
| CHEMBL4458074 | — | — | 1 | 4.64 |
| CHEMBL4468463 | — | — | 1 | 4.62 |
| CHEMBL4471273 | — | — | 1 | 4.38 |
| CHEMBL4474955 | — | — | 1 | 4.35 |
| CHEMBL4445249 | — | — | 1 | 4.30 |
| CHEMBL4447339 | — | — | 1 | 4.17 |
| CHEMBL4557522 | — | — | 1 | 4.15 |
| CHEMBL4464937 | — | — | 1 | 4.07 |
| CHEMBL4443790 | — | — | 1 | 4.06 |
| CHEMBL4474144 | — | — | 1 | 4.05 |
| CHEMBL4543417 | — | — | 1 | 4.01 |
| CHEMBL4475992 | — | — | 1 | - |
| CHEMBL4472475 | — | — | 1 | - |
| CHEMBL4459414 | — | — | 1 | - |
| CHEMBL4445785 | — | — | 1 | - |
| CHEMBL4461360 | — | — | 1 | - |
| CHEMBL4444907 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4537640 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4564211 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4439487 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL4557430 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4530236 | — | IC50 | = | 11430.0 | nM | 4.94 |
| CHEMBL4448269 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4467299 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4441228 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4539993 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4441086 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4551086 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL463165 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4458074 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL4468463 | — | IC50 | = | 23820.0 | nM | 4.62 |
| CHEMBL4471273 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL4474955 | — | IC50 | = | 44600.0 | nM | 4.35 |
| CHEMBL4445249 | — | IC50 | = | 50140.0 | nM | 4.30 |
| CHEMBL4447339 | — | IC50 | = | 66800.0 | nM | 4.17 |
| CHEMBL4557522 | — | IC50 | = | 70500.0 | nM | 4.15 |
| CHEMBL4464937 | — | IC50 | = | 85800.0 | nM | 4.07 |
| CHEMBL4443790 | — | IC50 | = | 86400.0 | nM | 4.06 |
| CHEMBL4474144 | — | IC50 | = | 89100.0 | nM | 4.05 |
| CHEMBL4543417 | — | IC50 | = | 97600.0 | nM | 4.01 |
| CHEMBL4538699 | — | IC50 | = | 142900.0 | nM | - |
| CHEMBL4549677 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4451137 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4454524 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4461061 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4586546 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4441012 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4452471 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4476274 | — | IC50 | = | 168200.0 | nM | - |
| CHEMBL4469999 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4557193 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4562784 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4459036 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4468240 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4531426 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4453970 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4553396 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4436593 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4444907 | — | IC50 | = | 132200.0 | nM | - |
| CHEMBL4461360 | — | IC50 | = | 196400.0 | nM | - |
| CHEMBL4445785 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4459414 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4472475 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4475992 | — | IC50 | > | 200000.0 | nM | - |