Assay Detail
Binding
CHEMBL4381690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISA
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CHEMBL4147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.07 | 6.10 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4556306 | — | — | 1 | 6.10 |
| CHEMBL4572769 | — | — | 1 | 6.09 |
| CHEMBL4515601 | — | — | 1 | 6.08 |
| CHEMBL28324 | — | — | 1 | 5.99 |
| CHEMBL4465628 | — | — | 1 | - |
| CHEMBL4445477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4556306 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4572769 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4515601 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL28324 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4465628 | — | Inhibition | - | % | - | |
| CHEMBL4445477 | — | Inhibition | - | % | - |