Assay Detail
Functional
CHEMBL4381715
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human U118MG cells assessed as reduction in cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-118-MG |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.21 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 7.05 |
| CHEMBL4466655 | — | — | 1 | 5.75 |
| CHEMBL4591115 | — | — | 1 | 5.54 |
| CHEMBL4298697 | — | — | 1 | 5.23 |
| CHEMBL4438521 | — | — | 1 | 5.12 |
| CHEMBL4450269 | — | — | 1 | 5.10 |
| CHEMBL4483778 | — | — | 1 | 4.98 |
| CHEMBL4543609 | — | — | 1 | 4.93 |
| CHEMBL4577179 | — | — | 1 | 4.76 |
| CHEMBL4459552 | — | — | 1 | 4.73 |
| CHEMBL1085588 | — | — | 1 | 4.07 |
| CHEMBL4448585 | — | — | 1 | - |
| CHEMBL4454912 | — | — | 1 | - |
| CHEMBL4449654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4466655 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4591115 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL4298697 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL4438521 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4450269 | — | IC50 | = | 7970.0 | nM | 5.10 |
| CHEMBL4483778 | — | IC50 | = | 10580.0 | nM | 4.98 |
| CHEMBL4543609 | — | IC50 | = | 11750.0 | nM | 4.93 |
| CHEMBL4577179 | — | IC50 | = | 17390.0 | nM | 4.76 |
| CHEMBL4459552 | — | IC50 | = | 18670.0 | nM | 4.73 |
| CHEMBL1085588 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL4448585 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4454912 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4449654 | — | IC50 | > | 50000.0 | nM | - |