Assay Detail
Binding
CHEMBL4381876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha9/alpha10 (CHEMBL2109238) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.38 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4460411 | — | — | 1 | 7.48 |
| CHEMBL4460879 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4460411 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4460879 | — | IC50 | = | 52.0 | nM | 7.28 |