Assay Detail
Binding
CHEMBL4381946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human IDO1 using L-tryptophan as substrate incubated under dark conditions measured after 60 mins by fluorescence microplate reader assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.17 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568628 | — | — | 1 | 7.34 |
| CHEMBL4445234 | — | — | 1 | 7.16 |
| CHEMBL584991 | — | — | 1 | 7.14 |
| CHEMBL4582983 | — | — | 1 | 7.13 |
| CHEMBL4580982 | — | — | 1 | 7.11 |
| CHEMBL4441847 | — | — | 1 | 7.09 |
| CHEMBL4462450 | — | — | 1 | 7.05 |
| CHEMBL4581625 | — | — | 1 | 7.01 |
| CHEMBL4458966 | — | — | 1 | 6.80 |
| CHEMBL4462121 | — | — | 1 | 6.62 |
| CHEMBL4590197 | — | — | 1 | 6.60 |
| CHEMBL4571947 | — | — | 1 | 6.35 |
| CHEMBL4435244 | — | — | 1 | 6.28 |
| CHEMBL4457918 | — | — | 1 | 6.20 |
| CHEMBL4458487 | — | — | 1 | 6.17 |
| CHEMBL4581891 | — | — | 1 | 6.02 |
| CHEMBL4459293 | — | — | 1 | 5.82 |
| CHEMBL4459816 | — | — | 1 | 5.68 |
| CHEMBL4444571 | — | — | 1 | 5.65 |
| CHEMBL4513280 | — | — | 1 | 5.60 |
| CHEMBL4580757 | — | — | 1 | 5.49 |
| CHEMBL4522620 | — | — | 1 | 5.45 |
| CHEMBL4553228 | — | — | 1 | 5.32 |
| CHEMBL4469299 | — | — | 1 | 5.21 |
| CHEMBL4546473 | — | — | 1 | 5.17 |
| CHEMBL4543491 | — | — | 1 | 5.09 |
| CHEMBL4443166 | — | — | 1 | 5.08 |
| CHEMBL4460536 | — | — | 1 | 5.02 |
| CHEMBL4540285 | — | — | 1 | - |
| CHEMBL4536106 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568628 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4445234 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL584991 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4582983 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4580982 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4441847 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4462450 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4581625 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4458966 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4462121 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4590197 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4571947 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4435244 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4457918 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4458487 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4581891 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4459293 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4459816 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL4444571 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4513280 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4580757 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4522620 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL4553228 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL4469299 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL4546473 | — | IC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL4543491 | — | IC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL4443166 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL4460536 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4529858 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4460373 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4458589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4470631 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4434768 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4535878 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4544661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467021 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4525225 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL4453836 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4444526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4463478 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4564513 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4568944 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4451709 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4469127 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4567684 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4534666 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4515286 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4536106 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4540285 | — | IC50 | > | 10000.0 | nM | - |