Assay Detail
Functional
CHEMBL4381956
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by MTT assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.14 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568628 | — | — | 1 | 7.55 |
| CHEMBL4445234 | — | — | 1 | 7.26 |
| CHEMBL4441847 | — | — | 1 | 7.17 |
| CHEMBL4582983 | — | — | 1 | 7.14 |
| CHEMBL4581625 | — | — | 1 | 7.04 |
| CHEMBL4580982 | — | — | 1 | 7.01 |
| CHEMBL4462450 | — | — | 1 | 7.00 |
| CHEMBL4457918 | — | — | 1 | 6.85 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.80 |
| CHEMBL4458966 | — | — | 1 | 6.62 |
| CHEMBL4458487 | — | — | 1 | 6.42 |
| CHEMBL4571947 | — | — | 1 | 6.39 |
| CHEMBL4462121 | — | — | 1 | 6.37 |
| CHEMBL4435244 | — | — | 1 | 6.36 |
| CHEMBL4590197 | — | — | 1 | 6.19 |
| CHEMBL4581891 | — | — | 1 | 5.97 |
| CHEMBL4543491 | — | — | 1 | 5.97 |
| CHEMBL4459293 | — | — | 1 | 5.94 |
| CHEMBL4459816 | — | — | 1 | 5.91 |
| CHEMBL4522620 | — | — | 1 | 5.90 |
| CHEMBL4444571 | — | — | 1 | 5.69 |
| CHEMBL4580757 | — | — | 1 | 5.56 |
| CHEMBL4443166 | — | — | 1 | 5.55 |
| CHEMBL4513280 | — | — | 1 | 5.53 |
| CHEMBL4469299 | — | — | 1 | 5.33 |
| CHEMBL4465967 | — | — | 1 | 5.14 |
| CHEMBL4437875 | — | — | 1 | 5.05 |
| CHEMBL4553228 | — | — | 1 | 4.86 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 4.79 |
| CHEMBL4546473 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568628 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4445234 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4441847 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4582983 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4581625 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4580982 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4462450 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4457918 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4458966 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4458487 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4571947 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4462121 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4435244 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4590197 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4581891 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4543491 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4459293 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4459816 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4522620 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4444571 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4580757 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL4443166 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL4513280 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL4469299 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL4465967 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL4437875 | — | IC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL4553228 | — | IC50 | = | 13690.0 | nM | 4.86 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 16270.0 | nM | 4.79 |
| CHEMBL4546473 | — | IC50 | = | 16520.0 | nM | 4.78 |
| CHEMBL4434768 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4535878 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4544661 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4536106 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4467021 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4525225 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4540285 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4515286 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4534666 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4567684 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4469127 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4451709 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4568944 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4564513 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4463478 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4460536 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4444526 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4453836 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4519463 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4529614 | — | IC50 | > | 20000.0 | nM | - |