Assay Detail
Binding
CHEMBL4382186
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Inhibition of human recombinant FAK using poly[Glu:Tyr] (4:1) substrate in presence of 10 mM ATP and [gamma33P]-ATP
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bifunctional Pyrimidines as Modulators of Focal Adhesion Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.03 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137331 | DEFACTINIB | 3.0 | 1 | 8.41 |
| CHEMBL4586249 | — | — | 1 | 8.33 |
| CHEMBL4541275 | — | — | 1 | 8.01 |
| CHEMBL4449796 | — | — | 1 | 7.97 |
| CHEMBL4567809 | — | — | 1 | 7.95 |
| CHEMBL4560289 | — | — | 1 | 7.90 |
| CHEMBL4558994 | — | — | 1 | 7.84 |
| CHEMBL4464368 | — | — | 1 | 7.83 |
| CHEMBL4447794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137331 | DEFACTINIB | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4586249 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4541275 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4449796 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL4567809 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL4560289 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL4558994 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL4464368 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4447794 | — | IC50 | = | 6.5 | nM | - |