Assay Detail
Binding
CHEMBL4382304
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Inhibition of EML4/ALK (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent dual ALK and EGFR T790M inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.73 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473365 | — | — | 1 | 8.15 |
| CHEMBL4449391 | — | — | 1 | 8.10 |
| CHEMBL4448107 | — | — | 1 | 7.70 |
| CHEMBL4467561 | — | — | 1 | 7.68 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 7.58 |
| CHEMBL4565984 | — | — | 1 | 7.41 |
| CHEMBL4531697 | — | — | 1 | 7.06 |
| CHEMBL4540442 | — | — | 1 | 6.66 |
| CHEMBL4520341 | — | — | 1 | 6.02 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 5.76 |
| CHEMBL4516287 | — | — | 1 | 5.66 |
| CHEMBL4581316 | — | — | 1 | 5.63 |
| CHEMBL4558227 | — | — | 1 | 5.60 |
| CHEMBL1229592 | — | — | 1 | 5.20 |
| CHEMBL4465103 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473365 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4449391 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4448107 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4467561 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2403108 | CERITINIB | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4565984 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4531697 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4540442 | — | EC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4520341 | — | EC50 | = | 961.0 | nM | 6.02 |
| CHEMBL3353410 | OSIMERTINIB | EC50 | = | 1748.0 | nM | 5.76 |
| CHEMBL4516287 | — | EC50 | = | 2182.0 | nM | 5.66 |
| CHEMBL4581316 | — | EC50 | = | 2357.0 | nM | 5.63 |
| CHEMBL4558227 | — | EC50 | = | 2506.0 | nM | 5.60 |
| CHEMBL1229592 | — | EC50 | = | 6258.0 | nM | 5.20 |
| CHEMBL4465103 | — | EC50 | > | 5000.0 | nM | - |