Assay Detail
Binding
CHEMBL4382906
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Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.33 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434024 | — | — | 1 | 8.40 |
| CHEMBL3087934 | — | — | 1 | 7.64 |
| CHEMBL2347861 | — | — | 1 | 6.70 |
| CHEMBL2347859 | — | — | 1 | 6.26 |
| CHEMBL2347858 | — | — | 1 | 6.10 |
| CHEMBL4564934 | — | — | 1 | 6.00 |
| CHEMBL4538679 | — | — | 1 | 5.89 |
| CHEMBL4577077 | — | — | 1 | 5.85 |
| CHEMBL4455060 | — | — | 1 | 5.70 |
| CHEMBL4471037 | — | — | 1 | 5.58 |
| CHEMBL4465832 | — | — | 1 | 5.52 |
| CHEMBL258994 | DIGERANYL BISPHOSPHONATE | — | 1 | - |
| CHEMBL4472025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434024 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3087934 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2347861 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2347859 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2347858 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4564934 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4538679 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4577077 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4455060 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4471037 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4465832 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL258994 | DIGERANYL BISPHOSPHONATE | IC50 | - | — | - | |
| CHEMBL4472025 | — | IC50 | > | 1000.0 | nM | - |