Assay Detail
Functional
CHEMBL4382911
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Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.04 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577077 | — | — | 1 | 6.85 |
| CHEMBL4538679 | — | — | 1 | 6.64 |
| CHEMBL4465832 | — | — | 1 | 6.34 |
| CHEMBL4455060 | — | — | 1 | 6.30 |
| CHEMBL4472025 | — | — | 1 | 6.16 |
| CHEMBL4471037 | — | — | 1 | 6.14 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 4.96 |
| CHEMBL434024 | — | — | 1 | 4.96 |
| CHEMBL258994 | DIGERANYL BISPHOSPHONATE | — | 1 | - |
| CHEMBL2347858 | — | — | 1 | - |
| CHEMBL2347859 | — | — | 1 | - |
| CHEMBL2347861 | — | — | 1 | - |
| CHEMBL4564934 | — | — | 1 | - |
| CHEMBL3087934 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4577077 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4538679 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4465832 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4455060 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4472025 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4471037 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4303669 | ZOLEDRONIC ACID | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL434024 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL258994 | DIGERANYL BISPHOSPHONATE | EC50 | - | — | - | |
| CHEMBL2347858 | — | EC50 | - | — | - | |
| CHEMBL2347859 | — | EC50 | - | — | - | |
| CHEMBL2347861 | — | EC50 | - | — | - | |
| CHEMBL4564934 | — | EC50 | - | — | - | |
| CHEMBL3087934 | — | EC50 | > | 100000.0 | nM | - |