Assay Detail
Functional
CHEMBL4382967
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Growth inhibition of human MV4-11 cells after 96 hrs by CCK8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 9.12 | 10.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4519362 | — | — | 1 | 10.46 |
| CHEMBL4558092 | — | — | 1 | 10.29 |
| CHEMBL4550750 | — | — | 1 | 10.18 |
| CHEMBL4546160 | — | — | 1 | 10.04 |
| CHEMBL4573649 | — | — | 1 | 9.86 |
| CHEMBL4449128 | — | — | 1 | 9.85 |
| CHEMBL4472522 | — | — | 1 | 9.44 |
| CHEMBL4215078 | — | — | 1 | 9.37 |
| CHEMBL4565270 | — | — | 1 | 9.33 |
| CHEMBL4520683 | — | — | 1 | 9.14 |
| CHEMBL4226052 | — | — | 1 | 8.98 |
| CHEMBL4469991 | — | — | 1 | 7.71 |
| CHEMBL4436396 | — | — | 1 | 7.59 |
| CHEMBL4094346 | — | — | 1 | 7.38 |
| CHEMBL4555209 | — | — | 1 | 7.25 |
| CHEMBL4572428 | — | — | 1 | - |
| CHEMBL4529557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4519362 | — | IC50 | = | 0.035 | nM | 10.46 |
| CHEMBL4558092 | — | IC50 | = | 0.051 | nM | 10.29 |
| CHEMBL4550750 | — | IC50 | = | 0.0654 | nM | 10.18 |
| CHEMBL4546160 | — | IC50 | = | 0.092 | nM | 10.04 |
| CHEMBL4573649 | — | IC50 | = | 0.138 | nM | 9.86 |
| CHEMBL4449128 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL4472522 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL4215078 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL4565270 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4520683 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4226052 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL4469991 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL4436396 | — | IC50 | = | 25.8 | nM | 7.59 |
| CHEMBL4094346 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4555209 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL4572428 | — | IC50 | = | 0.0083 | nM | - |
| CHEMBL4529557 | — | IC50 | > | 1000.0 | nM | - |