Assay Detail
Binding
CHEMBL4383162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Pseudomonas aeruginosa PAO1 NB52019 LpxC after 60 to 420 secs by SPR method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa PAO1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase (CHEMBL3855) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 9.76 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464418 | — | — | 1 | 10.59 |
| CHEMBL4517452 | — | — | 1 | 10.20 |
| CHEMBL4437188 | — | — | 1 | 10.19 |
| CHEMBL4514246 | — | — | 1 | 10.00 |
| CHEMBL4473969 | — | — | 1 | 9.92 |
| CHEMBL4466622 | — | — | 1 | 9.92 |
| CHEMBL4529054 | — | — | 1 | 9.92 |
| CHEMBL4471512 | — | — | 1 | 9.77 |
| CHEMBL4439209 | — | — | 1 | 9.77 |
| CHEMBL4456426 | — | — | 1 | 9.70 |
| CHEMBL4562023 | — | — | 1 | 9.70 |
| CHEMBL4569495 | — | — | 1 | 9.68 |
| CHEMBL4444870 | — | — | 1 | 9.52 |
| CHEMBL4462003 | — | — | 1 | 9.36 |
| CHEMBL260091 | — | — | 1 | 9.32 |
| CHEMBL4472717 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464418 | — | Kd | = | 0.026 | nM | 10.59 |
| CHEMBL4517452 | — | Kd | = | 0.063 | nM | 10.20 |
| CHEMBL4437188 | — | Kd | = | 0.065 | nM | 10.19 |
| CHEMBL4514246 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL4473969 | — | Kd | = | 0.12 | nM | 9.92 |
| CHEMBL4466622 | — | Kd | = | 0.12 | nM | 9.92 |
| CHEMBL4529054 | — | Kd | = | 0.12 | nM | 9.92 |
| CHEMBL4471512 | — | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL4439209 | — | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL4456426 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL4562023 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL4569495 | — | Kd | = | 0.21 | nM | 9.68 |
| CHEMBL4444870 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL4462003 | — | Kd | = | 0.44 | nM | 9.36 |
| CHEMBL260091 | — | Kd | = | 0.48 | nM | 9.32 |
| CHEMBL4472717 | — | Kd | = | 2.6 | nM | 8.59 |