Assay Detail
Functional
CHEMBL4383965
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Inhibition of PCSK9 mRNA expression in human HepG2 cells after 24 hrs by SYBR Green I dye-based qRT-PCR analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small molecules as inhibitors of PCSK9: Current status and future challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.62 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594001 | — | — | 1 | 6.44 |
| CHEMBL4573811 | — | — | 1 | 5.96 |
| CHEMBL3325762 | — | — | 1 | 5.50 |
| CHEMBL437412 | SCHISANDRIN C | — | 1 | 5.42 |
| CHEMBL2018876 | MORACIN C | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594001 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4573811 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3325762 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL437412 | SCHISANDRIN C | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL2018876 | MORACIN C | IC50 | = | 16800.0 | nM | 4.78 |