Assay Detail
Binding
CHEMBL4384327
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 24 hrs by q-PCR analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.22 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197589 | LG-190178 | — | 1 | 9.60 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.51 |
| CHEMBL1040 | CALCIFEDIOL ANHYDROUS | 4.0 | 1 | 6.40 |
| CHEMBL4449816 | — | — | 1 | 6.40 |
| CHEMBL3408015 | — | — | 1 | 6.40 |
| CHEMBL4542767 | — | — | 1 | 6.22 |
| CHEMBL4580825 | — | — | 1 | 6.05 |
| CHEMBL4524451 | — | — | 1 | 5.96 |
| CHEMBL4459512 | — | — | 1 | 5.89 |
| CHEMBL4522782 | — | — | 1 | 5.80 |
| CHEMBL4439766 | — | — | 1 | 5.80 |
| CHEMBL4438180 | — | — | 1 | 5.77 |
| CHEMBL4459996 | — | — | 1 | 5.64 |
| CHEMBL4582806 | — | — | 1 | 5.51 |
| CHEMBL4443970 | — | — | 1 | 5.42 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197589 | LG-190178 | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL846 | CALCITRIOL | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1040 | CALCIFEDIOL ANHYDROUS | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4449816 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3408015 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4542767 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4580825 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4524451 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4459512 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4522782 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4439766 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4438180 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4459996 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4582806 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4443970 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 82000.0 | nM | 4.09 |