Assay Detail
Binding
CHEMBL4384330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Hedgehog signaling pathway in mouse ASZ001 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 48 hrs by q-PCR analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.65 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197589 | LG-190178 | — | 1 | 9.64 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 7.40 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 7.05 |
| CHEMBL4459512 | — | — | 1 | 7.00 |
| CHEMBL4580825 | — | — | 1 | 6.70 |
| CHEMBL4582806 | — | — | 1 | 6.52 |
| CHEMBL4522782 | — | — | 1 | 6.40 |
| CHEMBL1040 | CALCIFEDIOL ANHYDROUS | 4.0 | 1 | 6.30 |
| CHEMBL4449816 | — | — | 1 | 6.30 |
| CHEMBL4542767 | — | — | 1 | 6.22 |
| CHEMBL4459996 | — | — | 1 | 6.22 |
| CHEMBL4524451 | — | — | 1 | 6.16 |
| CHEMBL4439766 | — | — | 1 | 6.00 |
| CHEMBL4443970 | — | — | 1 | 5.92 |
| CHEMBL4438180 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197589 | LG-190178 | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL846 | CALCITRIOL | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL4459512 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4580825 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4582806 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4522782 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1040 | CALCIFEDIOL ANHYDROUS | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4449816 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4542767 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4459996 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4524451 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4439766 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4443970 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4438180 | — | IC50 | = | 1300.0 | nM | 5.89 |