Assay Detail
Binding
CHEMBL4384334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.53 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197589 | LG-190178 | — | 1 | 8.11 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 7.00 |
| CHEMBL4459512 | — | — | 1 | 7.00 |
| CHEMBL4522782 | — | — | 1 | 6.40 |
| CHEMBL1040 | CALCIFEDIOL ANHYDROUS | 4.0 | 1 | 6.22 |
| CHEMBL4580825 | — | — | 1 | 6.22 |
| CHEMBL4524451 | — | — | 1 | 6.22 |
| CHEMBL4459996 | — | — | 1 | 6.16 |
| CHEMBL1042 | CHOLECALCIFEROL | 4.0 | 1 | 6.05 |
| CHEMBL4449816 | — | — | 1 | 5.89 |
| CHEMBL4438180 | — | — | 1 | - |
| CHEMBL4439766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197589 | LG-190178 | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4459512 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4522782 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1040 | CALCIFEDIOL ANHYDROUS | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4580825 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4524451 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4459996 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1042 | CHOLECALCIFEROL | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4449816 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4438180 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4439766 | — | EC50 | > | 10000.0 | nM | - |