Assay Detail
Binding
CHEMBL4384349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Hedgehog signaling pathway in Sufu-deficient mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 24 hrs by q-PCR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.37 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4580825 | — | — | 1 | 5.54 |
| CHEMBL3408015 | — | — | 1 | 5.51 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 5.07 |
| CHEMBL1042 | CHOLECALCIFEROL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4580825 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3408015 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL846 | CALCITRIOL | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1042 | CHOLECALCIFEROL | IC50 | > | 10000.0 | nM | - |