Assay Detail
Functional
CHEMBL4384477
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Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.19 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474417 | — | — | 1 | 7.16 |
| CHEMBL4441180 | — | — | 1 | 6.68 |
| CHEMBL4576103 | — | — | 1 | 6.52 |
| CHEMBL4437648 | — | — | 1 | 6.43 |
| CHEMBL4460798 | — | — | 1 | 6.41 |
| CHEMBL4450167 | — | — | 1 | 6.07 |
| CHEMBL4472369 | — | — | 1 | 6.06 |
| CHEMBL4450829 | — | — | 1 | 5.97 |
| CHEMBL4467221 | — | — | 1 | 5.95 |
| CHEMBL4464790 | — | — | 1 | 5.82 |
| CHEMBL4447154 | — | — | 1 | 5.80 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 5.80 |
| CHEMBL4463873 | — | — | 1 | 5.78 |
| CHEMBL4580962 | — | — | 1 | - |
| CHEMBL4455339 | — | — | 1 | - |
| CHEMBL4442084 | — | — | 1 | - |
| CHEMBL4438357 | — | — | 1 | - |
| CHEMBL4587136 | — | — | 1 | - |
| CHEMBL4476250 | — | — | 1 | - |
| CHEMBL4446869 | — | — | 1 | - |
| CHEMBL4455758 | — | — | 1 | - |
| CHEMBL4449021 | — | — | 1 | - |
| CHEMBL4435370 | — | — | 1 | - |
| CHEMBL4555347 | — | — | 1 | - |
| CHEMBL4452025 | — | — | 1 | - |
| CHEMBL4441559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474417 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4441180 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4576103 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4437648 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4460798 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4450167 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4472369 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4450829 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4467221 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4464790 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4447154 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4463873 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL4580962 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4455339 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4442084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438357 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4587136 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4476250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4446869 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4455758 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4449021 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4435370 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4555347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4452025 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4441559 | — | IC50 | > | 10000.0 | nM | - |