Assay Detail
Functional
CHEMBL4384479
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Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.26 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441180 | — | — | 1 | 5.69 |
| CHEMBL4474417 | — | — | 1 | 5.38 |
| CHEMBL4576103 | — | — | 1 | 5.35 |
| CHEMBL4460798 | — | — | 1 | 5.34 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 5.28 |
| CHEMBL4463873 | — | — | 1 | 5.23 |
| CHEMBL4450167 | — | — | 1 | 5.17 |
| CHEMBL4437648 | — | — | 1 | 5.14 |
| CHEMBL4455758 | — | — | 1 | 5.02 |
| CHEMBL4450829 | — | — | 1 | 5.01 |
| CHEMBL4447154 | — | — | 1 | - |
| CHEMBL4580962 | — | — | 1 | - |
| CHEMBL4455339 | — | — | 1 | - |
| CHEMBL4442084 | — | — | 1 | - |
| CHEMBL4555347 | — | — | 1 | - |
| CHEMBL4464790 | — | — | 1 | - |
| CHEMBL4472369 | — | — | 1 | - |
| CHEMBL4438357 | — | — | 1 | - |
| CHEMBL4587136 | — | — | 1 | - |
| CHEMBL4476250 | — | — | 1 | - |
| CHEMBL4446869 | — | — | 1 | - |
| CHEMBL4452025 | — | — | 1 | - |
| CHEMBL4449021 | — | — | 1 | - |
| CHEMBL4441559 | — | — | 1 | - |
| CHEMBL4435370 | — | — | 1 | - |
| CHEMBL4467221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441180 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4474417 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL4576103 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL4460798 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL4463873 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL4450167 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL4437648 | — | IC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL4455758 | — | IC50 | = | 9640.0 | nM | 5.02 |
| CHEMBL4450829 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL4447154 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4580962 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4455339 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4442084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4555347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4464790 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4472369 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438357 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4587136 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4476250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4446869 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4452025 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4449021 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4441559 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4435370 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467221 | — | IC50 | > | 10000.0 | nM | - |