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Assay Detail

CHEMBL4384531

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human MKN45 cells after 48 hrs by SRB assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MKN-45
Confidence 1 — Organism
Curated By Autocuration

Target

MKN-45 (CHEMBL614354)
Type CELL-LINE
Organism Homo sapiens

Publication

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.
Lai MJ, Ojha R, Lin MH, Liu YM, Lee HY, Lin TE, Hsu KC, Chang CY, Chen MC, Nepali K, Chang JY, Liou JP.
Eur J Med Chem (2019) 162 : 612 -630
PubMed 30476825 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.18 7.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4459443 1 7.20
CHEMBL4449487 1 7.11
CHEMBL4476134 1 6.89
CHEMBL4530114 1 6.85
CHEMBL20684 ABT-751 2.0 1 6.77
CHEMBL4576652 1 6.70
CHEMBL4470873 1 6.38
CHEMBL4438916 1 6.36
CHEMBL4442792 1 6.34
CHEMBL4518087 1 6.32
CHEMBL4532548 1 6.11
CHEMBL4534086 1 6.11
CHEMBL4579138 1 6.10
CHEMBL4439839 1 6.06
CHEMBL4437547 1 6.06
CHEMBL27759 ENTINOSTAT 3.0 1 5.92
CHEMBL4532324 1 5.68
CHEMBL4456789 1 5.64
CHEMBL4454685 1 5.60
CHEMBL4550855 1 5.41
CHEMBL4567256 1 5.30
CHEMBL4472441 1 5.00
CHEMBL4474258 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4459443 IC50 = 63.0 nM 7.20
CHEMBL4449487 IC50 = 78.0 nM 7.11
CHEMBL4476134 IC50 = 130.0 nM 6.89
CHEMBL4530114 IC50 = 140.0 nM 6.85
CHEMBL20684 ABT-751 IC50 = 170.0 nM 6.77
CHEMBL4576652 IC50 = 200.0 nM 6.70
CHEMBL4470873 IC50 = 420.0 nM 6.38
CHEMBL4438916 IC50 = 440.0 nM 6.36
CHEMBL4442792 IC50 = 460.0 nM 6.34
CHEMBL4518087 IC50 = 480.0 nM 6.32
CHEMBL4532548 IC50 = 780.0 nM 6.11
CHEMBL4534086 IC50 = 780.0 nM 6.11
CHEMBL4579138 IC50 = 800.0 nM 6.10
CHEMBL4439839 IC50 = 870.0 nM 6.06
CHEMBL4437547 IC50 = 880.0 nM 6.06
CHEMBL27759 ENTINOSTAT IC50 = 1200.0 nM 5.92
CHEMBL4532324 IC50 = 2100.0 nM 5.68
CHEMBL4456789 IC50 = 2300.0 nM 5.64
CHEMBL4454685 IC50 = 2500.0 nM 5.60
CHEMBL4550855 IC50 = 3900.0 nM 5.41
CHEMBL4567256 IC50 = 5000.0 nM 5.30
CHEMBL4472441 IC50 = 10000.0 nM 5.00
CHEMBL4474258 IC50 - -