Assay Detail
Binding
CHEMBL4384558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-CXCL12 from human CXCR4 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.13 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460491 | — | — | 1 | 8.00 |
| CHEMBL4452433 | — | — | 1 | 6.80 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 6.70 |
| CHEMBL4533528 | — | — | 1 | 6.70 |
| CHEMBL4463564 | — | — | 1 | 6.60 |
| CHEMBL4444949 | — | — | 1 | 6.60 |
| CHEMBL4558842 | — | — | 1 | 6.60 |
| CHEMBL4585865 | — | — | 1 | 6.50 |
| CHEMBL4557428 | — | — | 1 | 6.50 |
| CHEMBL4514484 | — | — | 1 | 6.50 |
| CHEMBL4438964 | — | — | 1 | 6.30 |
| CHEMBL4438705 | — | — | 1 | 6.30 |
| CHEMBL4445831 | — | — | 1 | 6.20 |
| CHEMBL4440964 | — | — | 1 | 6.10 |
| CHEMBL4539571 | — | — | 1 | 6.10 |
| CHEMBL4548557 | — | — | 1 | 6.10 |
| CHEMBL4561387 | — | — | 1 | 6.00 |
| CHEMBL4529593 | — | — | 1 | 6.00 |
| CHEMBL4463569 | — | — | 1 | 5.90 |
| CHEMBL4526858 | — | — | 1 | 5.70 |
| CHEMBL4450496 | — | — | 1 | 5.60 |
| CHEMBL4465129 | — | — | 1 | 5.60 |
| CHEMBL4585203 | — | — | 1 | 5.60 |
| CHEMBL4566356 | — | — | 1 | 5.50 |
| CHEMBL4460308 | — | — | 1 | 5.00 |
| CHEMBL4469048 | — | — | 1 | 5.00 |
| CHEMBL4463684 | — | — | 1 | 5.00 |
| CHEMBL4536186 | — | — | 1 | - |
| CHEMBL4469779 | — | — | 1 | - |
| CHEMBL4461446 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460491 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4452433 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4533528 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4463564 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4444949 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4558842 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4585865 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4557428 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4514484 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4438964 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4438705 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4445831 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4548557 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4539571 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4440964 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4529593 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4561387 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4463569 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4526858 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4450496 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4465129 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4585203 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4566356 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4469048 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4463684 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4460308 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4536186 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4469779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4461446 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4454166 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4443602 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226649 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4531030 | — | IC50 | > | 10000.0 | nM | - |