Assay Detail
Binding
CHEMBL4384566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of CXCL12-red from human NLuc-tagged CXCR4 receptor expressed in HEK293T cell membranes after 2 hrs by NanoBRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.58 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460491 | — | — | 1 | 8.00 |
| CHEMBL4438964 | — | — | 1 | 6.20 |
| CHEMBL4514484 | — | — | 1 | 6.10 |
| CHEMBL4452433 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460491 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4438964 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4514484 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4452433 | — | IC50 | = | 1000.0 | nM | 6.00 |