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Assay Detail

CHEMBL4384570

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Functional
Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

A Pair of Enantiomeric Bis- seco-abietane Diterpenoids from Cryptomeria fortunei.
Feng L, Mándi A, Tang C, Kurtán T, Tang S, Ke CQ, Shen N, Lin G, Yao S, Ye Y.
J Nat Prod (2018) 81 : 2667 -2672
PubMed 30485090 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.12 10.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL58 MITOXANTRONE 4.0 1 10.44
CHEMBL4594115 1 4.63
CHEMBL4582949 1 4.59
CHEMBL4449186 1 4.58
CHEMBL4435892 1 4.57
CHEMBL4471013 1 4.54
CHEMBL4469547 1 4.31
CHEMBL4474104 1 4.30
CHEMBL4553108 1 4.16
CHEMBL4482875 1 -
CHEMBL4469911 1 -
CHEMBL494660 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL58 MITOXANTRONE IC50 = 0.036 nM 10.44
CHEMBL4594115 IC50 = 23500.0 nM 4.63
CHEMBL4582949 IC50 = 25500.0 nM 4.59
CHEMBL4449186 IC50 = 26200.0 nM 4.58
CHEMBL4435892 IC50 = 26900.0 nM 4.57
CHEMBL4471013 IC50 = 28900.0 nM 4.54
CHEMBL4469547 IC50 = 48600.0 nM 4.31
CHEMBL4474104 IC50 = 50500.0 nM 4.30
CHEMBL4553108 IC50 = 68500.0 nM 4.16
CHEMBL4482875 IC50 > 100000.0 nM -
CHEMBL4469911 IC50 > 100000.0 nM -
CHEMBL494660 IC50 > 100000.0 nM -