Assay Detail
Functional
CHEMBL4384573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV JFH-1 infected in human Huh7.5.1 cells assessed as reduction in NS3/NS5A expression by Western blot analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.38 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4527813 | — | — | 1 | 4.70 |
| CHEMBL4555554 | — | — | 1 | 4.60 |
| CHEMBL4472700 | — | — | 1 | 4.52 |
| CHEMBL4459510 | — | — | 1 | 4.40 |
| CHEMBL431701 | SILYBIN A | 3.0 | 1 | 4.30 |
| CHEMBL592675 | SILYBIN B | — | 1 | 4.30 |
| CHEMBL4457931 | — | — | 1 | 4.30 |
| CHEMBL9509 | SILIBININ | 3.0 | 1 | 4.22 |
| CHEMBL4630684 | SILYMARIN | — | 1 | 4.10 |
| CHEMBL4435223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4527813 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4555554 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4472700 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4459510 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL431701 | SILYBIN A | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL592675 | SILYBIN B | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4457931 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL9509 | SILIBININ | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4630684 | SILYMARIN | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4435223 | — | IC50 | = | 200000.0 | nM | - |